Design
Twelve-month randomized dietary maintenance trial extension
Evidence chain
Population
256 adults with overweight or obesity after an eight-week low-calorie diet.
Intervention and comparator
High- or low-protein ad libitum diets, crossed with glycemic-index assignments and a control group.
Endpoint
Body-weight change during 12 months of maintenance.
Reported result
High-protein groups regained 2.0 kg less than low-protein groups in completers and 2.8 kg less in the intention-to-treat analysis.
Leptox interpretation
Supports a maintenance benefit in this post-weight-loss setting; it does not define a universal high-protein prescription.