Leptox

Intervention · INT-HIGH-PROTEIN

High-protein dietary intervention

Higher-protein patterns can support weight-loss maintenance in some randomized settings, but the effect depends on energy balance, adherence, comparator diet, and population.

Dietary patternDietary pattern that may alter satiety, energy intake, and lean-mass retentionModerate evidence

Evidence question

Does increasing dietary protein improve weight-loss maintenance?

Result / effect

In the 12-month DIOGENES extension, high-protein groups regained 2.0 kg less than low-protein groups in the completers analysis; the intention-to-treat difference was 2.8 kg.

Evidence chain

Population

Adults with overweight or obesity after an initial low-calorie weight-loss phase in the DIOGENES extension.

Endpoint

Weight regain during a 12-month maintenance period.

Evidence level

Moderate. Randomized evidence supports context-specific benefit, not a single universally optimal macronutrient target.

What this record does not establish

  • This evidence concerns maintenance after an initial weight-loss phase.
  • Adherence and food environment influence the observed effect.
  • A dietary pattern cannot be reduced to one branded product or supplement.

Linked study records

2014 · DIOGENES extensionWeight Loss Maintenance on Ad Libitum Diets with High or Low Protein Content and Glycemic IndexInternational Journal of Obesity↗

Sources